Can I turn off the 1st warning screen that always pops-up on navigation screen when I turn on my lexus GS350

l dont think so
you always have to agree
but you might read the manuel and it may have some way to do it

l will assume that this is not a 20 yr old car. SO if ya open the glove box, remove manual, read manual, do whut manual says, You will be O-tay !

No you can not. Lexus does that so you can not sue them if you get in an accident because of the navigation system. You just have to deal with it.

You might try updating the DVD disk. The new 08 Toyota is have a small disclaimer that pops up for about 10 secs and then disappears without you having to hit the '' l agree'' button. l know that Toyota retails them for $250. Go check out if the 08 is have the same feature in the GS and l am sure that the software upgrade will do the same for yours.